The Dynamics of Cardiovascular Biomarkers

The Dynamics of Cardiovascular Biomarkers in non-Elite Marathon Runners


Emma Roca, Lexa Nescolarde, Josep Lupón, Jaume Barallat, James L Januzzi, Peter Liu, M Cruz Pastor & Antoni Bayes-Genis


Blood samples were collected at baseline (24–48 h before the race), immediately after the race (1–2 h after the race), and 48-h post-race. Amino-terminal pro-B type natriuretic pep- tide (NT-proBNP, a marker of myocardial strain), ST2 (a marker of extracellular matrix remodeling and fibrosis, inflammation, and myocardial strain), and high-sensitivity troponin T (hs-TnT, a marker of myocyte stress/injury) were assayed. The median (interquartile range, IQR) years of training was 7 (5–11) years and median (IQR) weekly training hours was 6 (5–8) h/week, respectively. The median (IQR) race time (h:min:s) was 3:32:44 (3:18:50–3:51:46). Echocardiographic indices were within nor- mal ranges. Immediately after the race, blood concentration of the three cardiac biomarkers increased significantly, with 1.3-, 1.6-, and 16-fold increases in NT-proBNP, ST2, and hs-TnT, respectively. We found an inverse relationship between weekly training hours and increased ST2 (p = 0.007), and a direct rela- tionship between race time and increased hs-TnT (p < 0.001) and ST2 (p = 0.05). Our findings indicate that preparation for and participation in marathon running may affect multiple path- ways affecting the cardiovascular system. More data and long- term follow-up studies in non-elite and elite athletes are needed.

http://DOI 10.1007/s12265-017-9744-2

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