Training-Induced Gene Expression

Training-Induced Gene Expression Plasticity in Cardiac Function and Neural Regulation for Ultra-Trail Runners

Authors
María Maqueda, Emma Roca, Daniel Brotons, J. Manuel Soria, Alexandre Perera

Abstract
This study aims to assess the gene regulatory response from a group of 16 athletes and to observe the plasticity induced by their training regime on the gene expression
response after their participation in an 82km race. Blood samples for differential gene expression (DGE) were collected before and after this effort from two groups of
runners with different training regimes: elite and active. Analyses only focused on genes annotated as related to cardiac function (CF) and neural regulation (NR) from the KEGG PATHWAY Database. Thus, 13 pathways were considered accounting for a total of 629 genes. Training regime modulated the response to exercise based on a list of 18 ranked genes with significant DGE for elite runners while remained statistically insignificant for active athletes. UQCR11, COX7C and COX4I1 genes, related to mitochondrial respiratory chain, were downregulated which may indicate mitochondrial function impairment in cardiac muscle. Increased expression levels were obtained for PIK3R2, PLCG2, IRAK3 genes from the positive signaling cascades of neurotrophins
pathway, which may reveal an improved heart rate control thanks to a better cardiac sympathetic innervation.

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Desarrollo de una plataforma web

Desarrollo de una plataforma web para el acceso interactivo a una base de datos SQL con información biológica de competiciones deportivas

Autores

A. López del Río, M. Maqueda González, E. Roca Rodríguez, A. Perera Lluna

Objetivo

El objetivo de este trabajo es la construcción de una base de datos integrativa a partir de datos fisiológicos recogidos en cinco competiciones de trail, y la implementación de una aplicación web interactiva para proporcionar el fácil acceso y diseminación de la información almacenada.

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Independent components of gene expression in endurance run

Independent components of gene expression in endurance run

Authors

M. Maqueda, E. Roca, J. M. Soria, A. Perera

Abstract

We assessed the gene expression (GE) response from 16 endurance runners after participating in an ultra-trail (82km). Their genome-wide GE profile was quantified before and after the race with HuGene20st microarray:

• We obtained a list of 5,084 differential genes (DGs) being 37% down- regulated and 63% up-regulated.

• We carried out a global enrichment analysis to add biological interpretation. Overrepresented biological pathways were mostly associated with: genetic information processing, infectious diseases and immune system.

• We computed an independent component analysis (ICA) extracting five independent response blocks where, processes related to mitochondria, endocannabinoid system and angiogenesis emerged.

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Biochemical assessment of muscle damage

Biochemical assessment of muscle damage after mountain trail races

Authors
Cadefau, J, Carmona,G, Roca,E, Guerrero,M, Illera,V, Bedini,J, Cussó, R

Aim
The aim of the present study was to investigate the structural muscle damage by assessing the time course response of muscle enzymes and sarcomere fiber-type specific proteins in two groups of mountain runners performing a 35-km MTR or a 55-km MUM.

 

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How does the right ventricle adapt to high intensity endurance exercise?

How does the right ventricle adapt to high intensity endurance exercise? Insights from segmental myocardial deformation imaging.

Sanz de la Garza M, Grazioli G, Bijnens B, Pajuelo C, Guasch E, Subirats E, Brotons D, Brugada R, Roca E, Sitges M.

Background: Endurance exercise competitions have shown a transient negative effect on global right ventricular(RV) performance(dilationandworseningfunction),butwidevariabilityexistsamongindividuals. We aimed at understanding the physiologic response to exercise of the RV performance in different individuals undergoing similar competitions.

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High Interindividual differences in right ventricular acute adaptation

High Interindividual differences in right ventricular acute adaptation to exercise among cross-running racers.

Sanz M, Grazioli G, Bijnens B, Pajuelo C, Guasch E, Subirats E, Brugada R, Brotons D, Roca E, Sitges M

Background: Previous studies have shown a transient negative effect on the right ventricular (RV) performance. Potentially, this effect might be influenced by the type and intensity of the exercise performed. Currently, no data relates the exercise dose within a same sport competition and its influence on the RV performance. Therefore, we sought to assess acute changes in RV geometry and function according to the dose of exercise.

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Fonction vasculaire pulmonaire à l’effort

Fonction vasculaire pulmonaire à l’effort chez les sujets sains en moyenne altitude

Faoro V, Vicenzi M, Simaga B, Naeije R, Gaston A, Hapkova I, Doucende G, Roca E, Subirats E, Durand F, Deboeck G

L’objectif de cette étude est d’évaluer si la limitation cardiaque à l’effort observée en haute altitude apparait également à une altitude plus modérée et plus fréquentée (2250m).

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